| Wendy M. Mars, PhD, Director |
The roles of hepatocyte growth factor (HGF), IL-6, and elements of the plasminogen activator system in normal tissue regeneration, type 2 diabetes, fatty liver, and cirrhosis |
| Kalil G. Abdullah, MD, MSc |
Identifying vulnerable elements in glioma to facilitate rapid translational of therapeutics |
| Sameer Agnihotri, PhD |
Pediatric and adult high-grade gliomas (HGG) |
| Jonathan K. Alder, PhD |
Telomeres in human health and disease |
| Gavin E. Arteel, PhD* |
Investigating the magnitude and impact of the changes to the hepatic matrisome in the context of the development and recovery from liver disease |
| Stephen F. Badylak, DVM, PhD, MD |
Tissue engineering and regenerative medicine |
| Yaacov Barak, PhD |
Placenta; Adipose tissue |
| Michael J. Becich, MD, PhD |
Translational Bioinformatics in Pathology, Precision Oncology and Clinical Informatics |
| Juliane I. Beier, PhD |
Environmental vinyl chloride exposure in the context of existing underlying liver disease |
| Aaron W. Bell, PhD |
Understanding the role of transcription factors in control and regulation of liver growth, regeneration, differentiation and carcinogenesis |
| Kambez H. Benam, D.Phil |
Tissue Engineering, Organs-on-Chips, Host-Pathogen/Environment Interactions, Lung Pathophysiology, Immunobiology, Disease Modeling |
| Sarah Berman, MD, PhD |
The role of mitochondria in neurodegenerative diseases, including Parkinson's disease, Dementia with Lewy Bodies, and Alzheimer's disease |
| Bharat Bhushan, PhD |
Understanding the process of liver injury and compensatory liver regeneration during acute and chronic liver diseases. |
| Timothy R. Billiar, PhD |
Regulation and function of inducible nitric oxide synthase |
| Harry C. Blair, MD |
Bone physiology and pathology |
| Bryan Brown, PhD |
Inductive, Scaffold Based Regenerative Medicine, Host Innate Immune Interactions in Tissue Engineering and Regenerative Medicine |
| Ronald J. Buckanovich, MD, PhD |
Ovarian cancer novel basic biological phenomenon; developing therapeutic approaches and translated these findings back into clinic trials |
| Timothy F. Burns, MD, PhD |
Development of targeted therapies for KRAS-mutant NSCLC as well as novel strategies to overcome resistance to targeted therapies for EGFR-mutant and MET-altered non-small cell lung carcinoma |
| Anne-Ruxandra Carvunis, PhD |
The mechanisms of change and innovation in biological systems by integrating computational and experimental approaches |
| Stephen Y. Chan, MD, PhD |
The molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH) |
| Yuan Chang, MD |
Viral oncogenesis |
| Yvonne Chao, MD, PhD |
Understanding mechanisms of lymphatic metastasis |
| Yu-Chih Chen, PhD |
To establish comprehensive high-throughput multi-omics single-cell analysis including genome, epigenome, transcriptome, proteome, functional, and morphological methods |
| Charleen T. Chu, MD, PhD |
Neurodegeneration, neuroprotection and mitochondrial homeostasis; Parkinson's disease, Alzheimer's disease, Frontotemporal dementia; ophthalmic pathology |
| Lan G. Coffman, MD, PhD |
Investigating the role of the stromal microenvironment on ovarian cancer initiation, metastasis and treatment resistance |
| Christopher L. Cunningham, PhD |
Understanding the neural and sensory biology of the vertebrate auditory system |
| Marie C. DeFrances, MD, PhD |
PI3K signaling mechanisms in hepatocytes |
| Anthony J. Demetris, MD |
The role of inflammatory cytokines and growth factors in the development of cirrhosis & tolerance induction and chronic tissue rejection |
| Steven F. Dobrowolski, PhD |
Intoxicating type inborn errors of metabolism: genetics, genomic assessment to identify genetic modifiers of the primary phenotype(s), and the role of epigenetic modification in disease presentation |
| H. Henry Dong, PhD |
Insulin resistance to diabetic dyslipidemia and insulin replacement |
| Chris Donnelly, PhD |
The molecular pathogenesis of neurodegeneration and aging |
| Andrew W. Duncan, PhD |
Liver development, homeostasis and regeneration |
| Mo R. Ebrahimkhani, MD |
Organoids, Synthetic Morphogenesis, Genetic Engineering, Regeneration and Repair, Liver, Hematopoietic system |
| Toren Finkel, MD, PhD |
Mitochondrial function, cellular metabolism, oxidative stress, and aging |
| Ira J. Fox, MD |
Experimental therapies for liver disease |
| Subhadip Ghatak, PhD |
Exosome-mediated intercellular crosstalk in tissue regeneration and repair and the role of miRNA in wound healing |
| George Gittes, MD |
Diabetes gene therapy |
| Delphine Gomez, PhD |
The functional role of epigenetic and transcriptional mechanisms in controlling key properties of vascular smooth muscle cells (SMC) including cell differentiation, lineage memory and plasticity in the context of major cardiovascular diseases including atherosclerosis |
| Baoli Hu, PhD |
To understand the cellular and molecular mechanisms of brain tumor evolution, and to develop new therapies for these devastating diseases. |
| Hun-Way Hwang, MD, PhD |
mRNA regulation in both physiologic and disease scenarios with a special emphasis on 3-prime UTR-mediated regulation |
| George S. Hussey, PhD |
The discovery, development, and clinical translation of extracellular matrix (ECM)-based and other natural biopolymer materials for functional tissue reconstruction. |
| Smita Iyer, PhD |
Dr. Smita Iyer is an infectious disease immunologist whose research delves into the intricacies of CD4 T cells, exploring their role in antibody responses and in neuroinflammation caused by viruses like HIV, CMV, and SARS-CoV-2. |
| Brett Kaufman, PhD |
To understand the contribution of mtDNA metabolism to disease progression |
| Erin Kershaw, MD |
To forward the understanding and treatment of obesity and related metabolic disorders by combining basic and translational research with clinical expertise |
| John M. Kirkwood, MD |
To develop improved therapy for inoperable advanced melanoma |
| Corrine Kliment, MD, PhD |
Epithelial cell function in COPD and pulmonary fibrosis, cellular fate and senescence, airway and ciliary function, mitochondrial biology |
| Sungjin Ko, DVM, PhD* |
Beneficial modulation of cell fate using chemicals which regulate cellular programming of liver epithelial cells |
| Melanie Koenigshoff, MD, PhD |
Deciphering mechanisms involved in lung injury, aging and regeneration |
| Julia Kofler, MD |
Phenotype variation in Alzheimer's disease; Chronic Traumatic Encephalopathy; Pediatric Leukodystrophies |
| Gary Kohanbash, PhD |
Pediatric Brain Tumor Immunotherapy; theranostics; immunoPET; Biomarkers; Adoptive cellular therapy; peptide vaccine immunotherapy |
| Scott Kulich, MD, PhD |
The interaction between oxidative neurotoxins and intracellular signal transduction |
| Robert Lafyatis, MD |
Pathogenesis of systemic sclerosis, and its skin and pulmonary complications |
| Eric Lagasse, PharmD, PhD |
Human stem/progenitor cells for liver diseases |
| Gang Li, PhD |
To understand the molecular mechanisms underlying the contribution of disease-associated functional SNPs to the pathogenesis of, and the susceptibility to age-related diseases. |
| Hang Lin, PhD |
The etiology and pathogenesis of osteoarthritis, and aging-associated changes in the articular cartilage |
| Joseph Locker, MD, PhD |
Control of hepatocyte cell proliferation |
| Anna E. Lokshin, PhD |
Identification of cancer biomarkers for screening, diagnosis, prognosis, and disease monitoring of solid tumor cancers |
| Jianhua Luo, MD, PhD |
Cancer Genomics |
| Kacey G. Marra, PhD |
Tissue engineering peripheral nerve repair |
| George K. Michalopoulos, MD, PhD |
Using differentiated cells of the liver (hepatocytes) as models to understand the mechanisms that regulate growth of complex differentiated cells and whole organs |
| Pamela A. Moalli, MD, PhD |
Pelvic Floor Disorders and Prolapse Meshes |
| Satdarshan P. Singh Monga, MD |
Molecular mechanisms of liver growth and development, in health and disease |
| Mike Morowitz, MD |
Diet, the microbiome, and intestinal inflammation |
| Mousumi Moulik, MD |
Heart failure signaling |
| Benjamin Nacev, MD, PhD |
Understanding how cancer-associated genetic alterations in chromatin regulators promote cancer and to leverage this understanding to advance new therapeutic approaches in the clinic. |
| Jessie R. Nedrow, PhD |
The development of novel radiopharmaceuticals for molecular imaging and targeted radiotherapy therapy. |
| Kari N. Nejak-Bowen, MBA, PhD |
The cellular and molecular basis of liver injury, regeneration, and cholestatic liver disease |
| Yuri E. Nikiforov, MD, PhD |
Molecular mechanisms of radiation-induced carcinogenesis and chromosomal rearrangements in human cells and molecular basis of thyroid cancer |
| Michael Oertel, PhD |
Hepatic (stem) cell transplantation and tissue replacement in fibrotic liver |
| Steffi Oesterreich, PhD |
Endocrine resistance in breast cancer |
| Tim D. Oury, MD, PhD |
Oxidative stress and innate immunity in pulmonary disease |
| Andrey A Parkhitko, PhD |
To understanding of the metabolic mechanisms of aging and age-related diseases |
| Julie Phillippi, PhD |
Microvascular regeneration, ECM biomaterials, progenitor cells, aortic disease |
| Reben Raeman, MS, PhD |
Hepatic inflammation and fibrosis in non-alcoholic steatohepatitis (NASH) |
| Babak Razani, MD, PhD |
Understanding the mechanisms of common metabolic diseases. |
| Jeremy N. Rich, MD, MHS, MBA |
To identify novel therapeutic paradigms in the treatment of advanced cancers, primarily malignant brain tumors, through the prism of stem cell biology to identify core regulatory pathways amenable to pharmacologic targeting |
| Iain Scott, PhD |
Mitochondrial metabolism and bioenergetics |
| Melanie J Scott, MD, PhD |
Innate immune responses after surgery, trauma, hemorrhagic shock and infection |
| Ian A. Sigal, PhD |
Develop experimental, computational and imaging tools to understand the architecture and biomechanics of the eye and glaucoma |
| Kanhaiya Singh, PhD |
Tissue nanotransfection, electroceutical infection management, nanomedicine and bioinformatics with the aim to develop a simple and point-of-care approach to achieve targeted epigenetic editing of adult diabetic ischemic tissue in vivo |
| Rinda Soong, MD, PhD, MPH |
Dr. Soong's research interests focus on the pathogenesis, detection and prevention of women's cancers |
| Alejandro Soto-Gutierrez, MD, PhD, Associate Director |
Development of new technologies for liver function replacement using regenerative medicine approaches |
| Cynthia St. Hilaire, PhD |
The mechanisms that drive cell phenotype transitions and the interplay between extracellular matrix remodeling and vascular calcification in the context of both rare and common cardiovascular diseases |
| Donna Beer Stolz, PhD |
Optical and electron imaging technologies as they relate to cell and tissue biology |
| Kenichi (Ken) Tamama, MD, PhD, FCAP |
Cellular and molecular biology of mesenchymal stem cells |
| Roderick J. Tan, MD, PhD |
The molecular mechanisms underlying the development of acute kidney injury and chronic kidney disease. |
| Sina Tavakoli, MD, PhD |
Development of novel molecular and metabolic imaging strategies for early detection and risk stratification of cardiovascular and pulmonary diseases using PET and SPECT |
| Angus W. Thomson, PhD, DSc |
Regulatory immune cells, mTOR and transplant tolerance |
| Thanos Tzounopoulos, PhD |
The synaptic and intrinsic properties, and plasticity and pathology of auditory circuits and neurons |
| Ivona Vasile-Pandrea, MD, PhD |
SIV pathogenesis in progressive and nonprogressive hosts. Immune therapies for HIV infection |
| Dario A. Vignali, PhD |
Understanding of the inhibitory mechanisms that limit anti-tumor immunity in cancer and are insufficient in autoimmune disease |
| Flordeliza S. Villanueva, MD |
Development of ultrasound contrast agents (microbubbles) for assessment of the microcirculation, ultrasound molecular imaging, and ultrasound-mediated therapeutics |
| Nam Vo, PhD |
Role of metabolic regulation in aging biology of the intervertebral discs |
| Yoram Vodovotz, PhD |
Systems approaches to the biology of shock states, host-pathogen interactions, wound healing, and chronic inflammatory diseases |
| David Alan Vorp, PhD |
Vascular biomechanics |
| Jing Hong Wang, MD, PhD |
The mechanisms of tumorigenesis using B-cell lymphoma and head and neck squamous cell carcinomas (HNSCCs) as models |
| Xiaosong Wang, MD, PhD |
Integrative bioinformatics, cancer genetics, molecular cancer biology, and translational studies to identify genetic aberrations and appropriate cancer targets |
| Zhou Wang, PhD |
Androgen action and the roles of androgens in benign and cancerous prostate growth |
| Alan Wells, MD, DMS |
Cell and matrix communication in tissue physiology and pathology: exploring tumor progression and wound healing from molecular interactions through organismal biology using novel engineered models with a focus on all human systems |
| Sally E. Wenzel, MD |
Pathobiology of asthma |
| Clayton A. Wiley, MD, PhD |
Pathogenesis of neurodegenerative diseases and in particular on viral induced nervous system diseases |
| Cary Wu, PhD |
Cell adhesion: molecular mechanism and the roles in the pathogenesis of cancer and diabetic nephropathy |
| Haodi Wu, PhD |
Understand the mechanism of cardiac diseases with human induced pluripotent stem cell platform and CRISPR/Cas9 genome editing tools |
| Vijay K. Yechoor, MD |
Discovering regulatory mechanisms that control B-cell proliferation, function, and development as well as their application in prevention and therapy of diabetes |
| Reza Zarnegar, PhD |
The analysis of hepatocyte growth factor (HGF) and HGF receptor (a protooncogene) function and their genetic regulation at the molecular level in vivo |
| Lianghui (Lucy) Zhang, MD, PhD |
Lung vascular biology and immuno-pathogenesis of acute lung injury |
| Yingze Zhang, PhD |
The molecular and genetic basis of pulmonary and vascular diseases |
