Assistant Professor - Department of Medicine, Department of Pathology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine
Office Location (Address of Office):
UPMC Hillman Cancer Center
Research Pavilion
5117 Centre Avenue, Suite 2.6b
Pittsburgh, PA 15213
Contact Information:
Office Telephone: 412-623-7776
Email: nacevba@upmc.edu
Education & Training
MD, PhD: Johns Hopkins University School of Medicine
Internal Medicine Residency: Johns Hopkins Hospital
Medical Oncology Fellowship: Memorial Sloan Kettering Cancer Center
Postdoc: The Rockefeller University
Research Interests:
The scientific goal of the Nacev Lab is to understand how cancer-associated genetic alterations in chromatin regulators promote cancer and to leverage this understanding to advance new therapeutic approaches in the clinic. Specifically, we model these events and study how the epigenome is dysregulated to alter transcriptional and developmental programs important for cancer growth and oncogenic behavior. To do so, we employ diverse tools including genetic, chemical, and epigenomic approaches.
Lab website: https://nacevlab.com/
Selected Publications:
Complete publication list can be found here.
Nacev BA*, Sanchez-Vega F*, Smith SA, Antonescu CR, Rosenbaum E, Shi H, Tang C, Socci ND, Rana S, Gularte-Mérida R, Zehir A, Gounder MM, Bowler TG, Luthra A, Jadeja B, Okada A, Strong JA, Stoller J, Chan JE, Chi P, D’Angelo SP, Dickson MA, Kelly CM, Keohan ML, Movva S, Thornton K, Meyers PA, Wexler LH, Slotkin EK, Glade Bender JL, Shukla NN, Hensley ML, Healey JH, La Quaglia MP, Alektiar KM, Crago AM, Yoon SS, Untch BR, Chiang S, Agaram NP, Hameed MR, Berger MF, Solit DB, Schultz N, Ladanyi M, Singer S, Tap WD. Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nat Commun. 2022; PMID: 35705560
Nacev BA, Feng L, Bagert JD, Lemiesz AE, Gao J, Soshnev AA, Kundra R, Schultz N, Muir TW, Allis CD. The expanding landscape of ‘oncohistone’ mutations in human cancers. Nature. 2019 Mar 20. 2019 Mar;567(7749):473-478.