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Research Interests
- Development of novel molecular and metabolic imaging strategies for early detection and risk stratification of cardiovascular and pulmonary diseases using PET and SPECT.
- Targeted imaging of inflammation, extra-cellular matrix remodeling, and fibrosis utilizing pre-clinical and translational approaches.
Selected Publications
- Haddad J, Latoche JD, Nigam S, Bellavia MC, Day KE, Zhu Q, Edwards, Anderson CJ, Tavakoli S. Molecular imaging of very late antigen-4 (VLA-4) in acute lung injury. Journal of Nuclear Medicine (In Press). PMID: 32680928, DOI: 10.2967/jnumed.120.242347
- Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Characterization of macrophage polarization states using combined measurement of 2-deoxyglucose and glutamine accumulation: Implications for imaging of atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology. 2017; 37: 1840-1848. PMID: 28798141, DOI: 10.1161/ATVBAHA.117.308848
- Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential regulation of macrophage glucose metabolism by M-CSF and GM-CSF: Implications for 18F-FDG PET imaging of vessel wall inflammation. Radiology. 2017; 283: 87-97. PMID: 27849433, PMCID: PMC5375627, DOI: 10.1148/radiol.2016160839
- Tavakoli S, Zamora D, Zamora D, Ullevig S, Asmis R. Bioenergetic profiles diverge during macrophage polarization: Implications for the interpretation of 18F-FDG PET imaging of atherosclerosis. Journal of Nuclear Medicine. 2013; 54: 1661-1667. PMID: 23886729, PMCID: PMC4037161, DOI: 10.2967/jnumed.112.119099
- Tavakoli S, Razavian M, Zhang J, Nie L, Marfatia R, Dobrucki LW, Sinusas AJ, Robinson S, Edwards DS, Sadeghi MM. Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011; 31: 102-109. PMID: 20947820, PMCID: PMC3005135, DOI: 10.1161/ATVBAHA.110.216036
