Research Interests
Currently, Dr. Billiar is involved in several research projects within the Billiar Lab. The main research interest of the laboratory is the regulation and function of inducible nitric oxide synthase (iNOS). Other areas of interest include apoptosis, gene therapy, hypoxia, shock, inflammation and liver disease. Dr. Billiar's lab is a prime example of a productive and well-funded lab with both PhDs and MDs working together in a coordinated fashion for the pursuit of knowledge and the advancement of science.
As a result of his research, Dr. Billiar has gained an international reputation for his contributions to understanding the role of nitric oxide in gene therapy, trauma, liver disease, and other potential clinical applications. He holds six US patents associated with his research.
Selected Publications
View Dr. Billiar's publications on PubMed
Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH; Inflammation and Host Response to Injury Program, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG 2nd, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proceedings of the National Academy of Sciences U S A. 2010 Jun 1;107(22):9923-8. Epub 2010 May 17. PMCID: 2890487.
Buchholz BM, Billiar TR, Bauer AJ. Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2010 May 27. PMCID: 2928536. [Epub ahead of print]
Nakao A, Kaczorowski DJ, Wang Y, Cardinal JS, Buchholz BM, Sugimoto R, Tobita K, Lee S, Toyoda Y, Billiar TR, McCurry KR. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. Journal of Heart and Lung Transplantation. 2010 May;29(5):544-53. Epub 2009 Dec 24. PMID: 20036162.
Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Hemorrhagic Shock Activates Lung Endothelial NAD(P)H Oxidase via Neutrophil NADPH Oxidase. American Journal of Respiratory Cell and Molecular Biology. 2010 Apr 23. PMCID: 3095934. [Epub ahead of print]
Kaczorowski DJ, Afrazi A, Scott MJ, Kwak JH, Gill R, Edmonds RD, Liu Y, Fan J, Billiar TR. Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. Journal of Leukocyte Biology. 2010 Apr 22. PMCID: 2974428. [Epub ahead of print]
Prince JM, Vodovotz Y, Baun MJ, Monga SP, Billiar TR, Gerlach JC. The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support. Tissue Engineering Part A. 2010 Mar;16(3):861-6. PMCID: 2862614.
Sengupta R, Billiar TR, Kagan VE, Stoyanovsky DA. Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells. Biochemical and Biophysical Research Communications. 2010 Jan 1;391(1):1127-30. PMCID: 2812598. Epub 2009 Dec 11.
Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR, Nakao A. Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International. 2010 Jan;77(2):101-9. PMID: 19907413. Epub 2009 Nov 11.
Namas R, Ghuma A, Torres A, Polanco P, Gomez H, Barclay D, Gordon L, Zenker S, Kim HK, Hermus L, Zamora R, Rosengart MR, Clermont G, Peitzman A, Billiar TR, Ochoa J, Pinsky MR, Puyana JC, Vodovotz Y. An adequately robust early TNF-α response is a hallmark of survival following trauma/hemorrhage. PLoS One. 2009 Dec 22;4(12):e8406. PMCID: 2794373.
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