Roderick J. Tan, MD, PhD

Research Interests

My lab is interested in identifying the molecular mechanisms that contribute to the development of acute kidney injury and chronic kidney disease. We utilize a combination of in vivo animal models (experimental models of disease, conditional knockout mice) and in vitro (tubular and podocyte cell culture) methods. Our research has revealed that the Keap1/Nrf2 pathway protects against AKI-to-CKD progression but may also have a paradoxical role in promoting proteinuria and podocyte/glomerular injury. We are studying the role of MCP-1 and Wnt/beta-catenin on proteinuria and kidney fibrosis. We are collaborating on projects to identify and characterize microvascular rarefaction in the kidney with super-resolution ultrasound in both animal models and human subjects. Our overall goal is to improve the understanding, diagnosis, and treatment of kidney disease using a translational bench-to-bedside approach.

 

Selected Publications

  1. Tan RJ, Li Y, Rush BM, Cerqueira DM, Zhou D, Fu H, Ho J, Beer Stolz D, Liu Y. Tubular injury triggers podocyte dysfunction by ?-catenin-driven release of MMP-7. JCI Insight. 2019 Dec 19;4(24). doi: 10.1172/jci.insight.122399. PubMed PMID: 31743113; PubMed Central PMCID: PMC6975262.
  2. Rush BM, Small SA, Stolz DB, Tan RJ. An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney. J Vis Exp. 2018 Nov 1;(141). doi: 10.3791/58162. PubMed PMID: 30451231; PubMed Central PMCID: PMC6688477.
  3. Jobbagy S, Tan RJ. Nitrolipids in kidney physiology and disease. Nitric Oxide. 2018 Mar 29;. doi: 10.1016/j.niox.2018.03.021. [Epub ahead of print] Review. PubMed PMID: 29605557; PubMed Central PMCID: PMC6163094.
  4. Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep. 2016 Nov 2;6:36185. doi: 10.1038/srep36185. PubMed PMID: 27804998; PubMed Central PMCID: PMC5090361.
  5. Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol. 2015 Oct;26(10):2447-59. doi: 10.1681/ASN.2014060613. Epub 2015 Feb 2. PubMed PMID: 25644107; PubMed Central PMCID: PMC4587687.
  6. Tan RJ, Zhou D, Zhou L, Liu Y. Wnt/?-catenin signaling and kidney fibrosis. Kidney Int Suppl (2011). 2014 Nov;4(1):84-90. doi: 10.1038/kisup.2014.16. Review. PubMed PMID: 26312156; PubMed Central PMCID: PMC4536962.
  7. Tan RJ, Zhou L, Zhou D, Lin L, Liu Y. Endothelin receptor a blockade is an ineffective treatment for adriamycin nephropathy. PLoS One. 2013;8(11):e79963. doi: 10.1371/journal.pone.0079963. eCollection 2013. PubMed PMID: 24265790; PubMed Central PMCID: PMC3825716.
  8. Tan RJ, Fattman CL, Niehouse LM, Tobolewski JM, Hanford LE, Li Q, Monzon FA, Parks WC, Oury TD. Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in mice. Am J Respir Cell Mol Biol. 2006 Sep;35(3):289-97. doi: 10.1165/rcmb.2005-0471OC. Epub 2006 Mar 30. PubMed PMID: 16574944; PubMed Central PMCID: PMC1820635.
  9. Tan RJ, Lee JS, Manni ML, Fattman CL, Tobolewski JM, Zheng M, Kolls JK, Martin TR, Oury TD. Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. Am J Respir Cell Mol Biol. 2006 Feb;34(2):226-32. doi: 10.1165/rcmb.2005-0212OC. Epub 2005 Oct 13. PubMed PMID: 16224105; PubMed Central PMCID: PMC2644184.