Jennifer Picarsic, MD

Dr. Picarsic's interests include investigating the pathologic, molecular, and clinical characterization of benign and malignant pediatric histiocytic neoplasms including 1.) Langerhans cells histiocytosis (LCH) with unusual presentations while correlating the histopathology of recurrent and clinically low-grade diseases that cause long-term permanent consequences with molecular integration in blood and tissues: 1a) Expanding the pathologic understanding of brain involvement with non-tumorous mutant histiocytic infiltrates which causes white matter injury with gliosis, demyelination, and neurodegenerative sequelae; 1b) Expanding the pathologic understanding of liver/bile duct involvement in histiocytic disorders and pathogenesis which driving liver fibrosis in LCH patients; and 1c) Expanding the pathologic understanding of bone marrow involvement in histiocytic disorders. 2. LCH disease and the impact of mutation on phenotypic alterations. 3) Non-LCH disease presentations of NTRK1 rearranged histiocytosis and other molecular drivers in juvenile xanthogranuloma family of lesions. 4.) Malignant histiocytosis -nomenclature updates and investigating the histopathology correlates that associate with worse outcome using novel pathology models.