Dr. Xu is a member of the Division of Experimental Pathology.
Education & Training
PhD - 2004, University of Fukui, Japan
Research Interests
The research interest is to assess the efficacy of antiretroviral treatments (ART) on the mucosal immune activation and inflammation, mucosal integrity, microbial translocation and microbiome.
Representative Publications
- Pharmacokinetics and Immunological Effects of Romidepsin in Rhesus Macaques. Kleinman AJ, Xu C, Cottrell ML, Sivanandham R, Brocca-Cofano E, Dunsmore T, Kashuba A, Pandrea I, Apetrei C.Front Immunol. 2020 Dec 11;11:579158. doi: 10.3389/fimmu.2020.579158. eCollection 2020.PMID: 33362765
- Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus. Sivanandham R, Kleinman AJ, Sette P, Brocca-Cofano E, Kilapandal Venkatraman SM, Policicchio BB, He T, Xu C, Swarthout J, Wang Z, Pandrea I, Apetrei C.J Virol. 2020 Sep 15;94(19):e00533-20. doi: 10.1128/JVI.00533-20. Print 2020 Sep 15.PMID: 32669326
- African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity. Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I.PLoS Pathog. 2020 Mar 2;16(3):e1008333. doi: 10.1371/journal.ppat.1008333. eCollection 2020 Mar.PMID: 32119719
- High-fat diet exacerbates SIV pathogenesis and accelerates disease progression. He T, Xu C, Krampe N, Dillon SM, Sette P, Falwell E, Haret-Richter GS, Butterfield T, Dunsmore TL, McFadden WM Jr, Martin KJ, Policicchio BB, Raehtz KD, Penn EP, Tracy RP, Ribeiro RM, Frank DN, Wilson CC, Landay AL, Apetrei C, Pandrea I.J Clin Invest. 2019 Dec 2;129(12):5474-5488. doi: 10.1172/JCI121208.PMID: 31710311
- Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control. Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr.Nat Commun. 2019 Nov 8;10(1):5101. doi: 10.1038/s41467-019-12987-9.PMID: 31704931