Education
- MD - 1981, University of Florida
Clinical Expertise
Dr. Wenzel is considered a global expert in severe asthma. She has pioneered the concept of asthma phenotypes, including the progression to molecular phenotyping. Dr. Wenzel and Dr. Samuel Yousem were the first to identify a new disease, termed asthmatic granulomatosis, which has features of asthma and autoimmune-like disease.
Research Interests
Dr. Wenzel's research interest derives from her clinical experience. She often follows a bedside to bench approach, regarding biomarkers and relation to asthma phenotypes and treatment. Additionally, she is currently involved in multiple "omics" projects, including gene expression profiling in human airway cell from a range of asthmatics and controls. She is directly involved in better understanding the impact of Type-2 inflammation on human airway epithelial cells and is able to match cultured/experimental cells with fresh cells, obtained directly from asthmatic patients. She utilizes these cells to model immune processes in asthma in vitro. She has also been interested in the convergence of additional immune pathways with Type-2 inflammation, particularly that related to Type-1 inflammation.
Certifications
Internal Medicine, Pulmonary Medicine
Awards and Honors
- 2005 - ATS – Elizabeth A. Rich MD Award
- 2005 - Colorado ALA President's Award
- 2010 - American Thoracic Society Recognition Award for Scientific Accomplishment
- 2011 - John E. Salvaggio Memorial Lectureship, AAAAI
- 2017 - ERS Presidential Award
- 2018 - Ladies Hospital Aid Society Trailblazer Awardee
- Best Doctors in America 2001 – Present
Selected Publications
View Dr. Wenzel's publications on PubMed
- Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayir H, Kagan VE. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044. PMID: 29053969. PMCID: PMC5683852.
- Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, Eckert L, Graham NM, Stahl N, Yancopoulos GD, Louis-Tisserand M, Teper A. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting ß2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet. 2016 Jul 2;388(10039):31-44. doi: 10.1016/S0140-6736(16)30307-5. Epub 2016 Apr 27. PMID: 27130691.
- Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, Graham N, Pirozzi G. Dupilumab in Persistent Asthma with Elevated Eosinophil Levels. N Engl J Med 2013 368(26): 2455-2466. PMID: 23688323.
- Wenzel SE. Asthma phenotypes: Evolution from clinical to molecular approaches. Nat Med. 2012 May 4; 18(5):716-25. PMID: 22561835.
- Modena BD, Tedrow JR, Milosevic J, Bleecker ER, Meyers DA, Wu W, Bar-Joseph Z, Erzurum SC, Gaston BM, Busse WW, Jarjour NN, Kaminski N, Wenzel SE. Gene Expression in Relation to Exhaled NO Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways. Am J Respir Crit Care Med. 2014 Dec 15;190(12):1363-72. PMID: 25338189. PMCID: PMC4294630.