Jeffrey L. Fine, MD

Associate Professor of Pathology, Magee-Womens Hospital Pathology, Division of Pathology Informatics

Dr. Fine is a member of the Division of Breast and Gynecologic Pathology. He is also the Director, Subdivision of Advanced Imaging and Image Analysis (Pathology Informatics).

Clinical Expertise

  • Breast Pathology, including Breast Cancer biomarker testing
  • Gynecologic Pathology, including Cancer biomarker testing
  • Digital Pathology, including Image Analysis and Telepathology


  • Anatomic and Clinical Pathology, 2005 (Voluntary Re-certification, 2013)
Education & Training
MD - Ohio State University, 2000
AP/CP Pathology Residency - Cleveland Clinic, 2005
Pathology Informatics Fellowship - University of Pittsburgh, 2006
Certificate, Biomedical Informatics - University of Pittsburgh, 2006
Research Interests
  • Computational Pathology (AI)
  • Computer Assisted Diagnosis for Pathologists (pCAD)
  • Multiplexed Fluorescence applications
  • In Vivo and Ex Vivo Microscopy (IVM/EVM), including Optical Coherence Tomography
Representative Publications

View Dr. Fine's publications on PubMed

  • Tosun AB, Nguyen L, Ong N, Navolotskaia O, Carter G, Fine JL, Taylor DL, Chennubhotla SC. Histological Detection of High-Risk Benign Breast Lesions from Whole Slide Images. Medical Image Computing and Computer-Assisted Intervention (MICCAI 2017). Lecture Notes in Computer Science, vol 10434. Springer, Cham (
  • Farahani N, Liu Z, Jutt D, Fine JL. Pathologists' Computer-Assisted Diagnosis: A Mock-up of a Prototype Information System to Facilitate Automation of Pathology Sign-out. Arch Pathol Lab Med. 2017 Jul 7. [Epub ahead of print] PMID: 28686499.
  • Nguyen L, Tosun AB, Fine J, Lee A, Taylor DL, Chennubhotla C. Spatial statistics for segmenting histological structures in H&E stained tissue images. IEEE Trans Med Imaging. 2017 Mar 16. doi: 10.1109/TMI.2017.2681519. [Epub ahead of print]
  • Cao C, Vasilatos SN, Bhargava R, Fine JL, Oesterreich S, Davidson NE, Huang Y. Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression. Oncogene. 2017 Jan 5. 36(1):133-145. doi: doi:10.1038/onc.2016.186.
  • Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC. Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers. J Pathol Inform. 2016;7:47.
  • Farahani N, Post R, Duboy J, Ahmed I, Kolowitz BJ, Krinchai T, Monaco SE, Fine JL, Hartman DJ, Pantanowitz L. Exploring virtual reality technology and the Oculus Rift for the examination of digital pathology slides. J Pathol Inform. 2016;7:22.
  • Fitzmaurice M, Fine JL, Fischer AH, Kaufman JH, Mathur SC, Mirkovic J, Rao BK, Shevchuk MM, Sussman LK, Vajpeyi R, editors. In vivo microscopy resource guide. Version 7.0. Northfield, IL: College of American Pathologists; 2016.
  • Nayak SR, Harrington E, Boone D, Hartmaier R, Chen J, Pathiraja TN, Cooper KL, Fine JL, Sanfilippo J, Davidson NE, Lee AV, Dabbs D, Oesterreich S. A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer. Horm Cancer. 2015 Dec;6(5-6):214-24.
  • Bruhat A, Combrinck M, Dalimier E, Harms F, Fine JL. Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer. Proc SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032Y; 2015.
  • Fine JL. 21st Century Workflow: A Proposal. J. Pathol. Inform. 2014;5:44.