Dr. John is a member of the Division of Anatomic Pathology and the Director of Bone and Soft Tissue Pathology Center of Excellence.
Clinical Expertise
Bone and soft tissue pathology
Education & Training
MBBS - Kasturba Medical College, Manipal
Pathology Residency (Chief) - SUNY Upstate Medical University
Surgical Pathology Fellowship - Mayo Clinic
Bone and Soft Tissue Fellowship - University of Pittsburgh Medical Center
Research Interests
Dr. John's research interests are focused on histopathologic and molecular characterization of bone and soft tissue tumors, with an emphasis on translocation associated sarcomas, and detection of biomarkers that can be used clinically for the diagnosis, prognostication and treatment of bone and soft tissue sarcomas.
Representative Publications
- Michal M, Rubin BP, Agaimy A, Kosemehmetoglu K, Rudzinski ER, Linos K, John I, Gatalica Z, Davis JL, Liu YJ, McKenney JK, Billings SD, Švajdler M, Koshyk O, Kinkor Z, Michalová K, Kalmykova AV, Yusufli Z, Ptáková N, Hájková V, Grossman P, Šteiner P, Michal M. EWSR1-PATZ1-rearranged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers. Mod Pathol. 2020 Oct 4;. doi: 10.1038/s41379-020-00684-8. [Epub ahead of print] PMID: 33012788.
- Lopez-Nunez O, Surrey LF, Alaggio R, Herradura A, McGough RL, John I. Novel APOD-GLI1 rearrangement in a sarcoma of unknown lineage. Histopathology. 2020 Aug 15;. doi: 10.1111/his.14235. [Epub ahead of print] PMID: 32798311.
- Lopez-Nunez O, Surrey LF, Alaggio R, Fritchie KJ, John I. Novel PPP1CB-ALK fusion in spindle cell tumor defined by S100 and CD34 coexpression and distinctive stromal and perivascular hyalinization. Genes Chromosomes Cancer. 2020 Aug;59(8):495-499. doi: 10.1002/gcc.22844. Epub 2020 Apr 4. PMID: 32222087.
- Lopez-Nunez O, Alaggio R, Ranganathan S, Schmitt L, John I, Church AJ, Picarsic J. New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. Hum Pathol. 2020 Jul 18;104:30-41. doi: 10.1016/j.humpath.2020.07.016. [Epub ahead of print] PMID: 32692992.
- Berklite L, Ranganathan S, John I, Picarsic J, Santoro L, Alaggio R. Fibrous histiocytoma/dermatofibroma in children: the same as adults?. Hum Pathol. 2020 May;99:107-115. doi: 10.1016/j.humpath.2020.03.012. Epub 2020 Apr 1. PMID: 32246988.
- Lopez-Nunez O, John I, Panasiti RN, Ranganathan S, Santoro L, Grélaud D, Wu T, Buccoliero AM, Casanova M, Alaggio R, Surrey LF. Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases. Mod Pathol. 2020 Apr;33(4):576-590. doi: 10.1038/s41379-019-0406-6. Epub 2019 Nov 5. PMID: 31690781.
- John I, Inwards CY, Wenger DE, Williams DD, Fritchie KJ. Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histological features and skeletal distribution. Histopathology. 2020 Jan;76(2):308-317. doi: 10.1111/his.13972. Epub 2019 Nov 26. PMID: 31429985.
- John I, Fritchie KJ. What is new in pericytomatous, myoid, and myofibroblastic tumors?. Virchows Arch. 2020 Jan;476(1):57-64. doi: 10.1007/s00428-019-02700-y. Epub 2019 Nov 8. Review. PMID: 31705190.
- Waters R, Horvai A, Greipp P, John I, Demicco EG, Dickson BC, Tanas MR, Larsen BT, Ud Din N, Creytens DH, Bahrami A, Doyle LA, Jo VY, Al-Ibraheemi A, Thway K, Jenkins SM, Siontis B, Folpe A, Fritchie K. Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged ? 40 years: a study of 116 patients. Histopathology. 2019 Dec;75(6):833-842. doi: 10.1111/his.13957. Epub 2019 Oct 13. PMID: 31471922.
- Fernandez-Valdivia R, Chammaa M, Goebel D, John I, Beydoun R. Expression of Notch Receptors and Ligands in the Coccygeal Body. Neuro Endocrinol Lett. 2019 Nov;40(4):184-194. PMID: 32087094.
- John I, Folpe AL. Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathologic Study of 17 Soft Tissue Cases Showing a Predilection for the Paraspinal Region. Am J Surg Pathol. 2016 Aug;40(8):1084-9. doi: 10.1097/PAS.0000000000000627. PMID: 26945338.