Douglas J. Hartman, MD

Associate Professor of Pathology, Division of Anatomic Pathology, Director, Division of Pathology Informatics

Dr. Hartman is a member of the Division of Anatomic Pathology. He is also the Vice Chair of the Pathology Informatics Division and Director of Image Analysis Laboratory.

Clinical Expertise

Dr. Hartman is an Academic Surgical Pathologist with a subspecialty interest and focus in Gastrointestinal and Pancreatic pathology. He also consults on surgical pathology cases involving the luminal GI tract and pancreas. He also has developed and deployed automated image analysis as well machine learning for clinical diagnostic support.

Certifications

  • Diplomate of the American Board of Pathology in combined Anatomic Pathology and Clinical Pathology
  • Diplomate of the American Board of Pathology in Clinical Informatics

Specialties

Surgical Pathologist with subspecialty interest and training in gastrointestinal / pancreatic pathology

Professional Affiliations

  • United States and Canadian Association of Pathology 2008-Present
  • College of American Pathologists 2008-Present
  • American Society for Clinical Pathology 2008-Present

Major Lectureships

  • Pittsburgh Pathology Society January 2018 "Update on Inflammatory Bowel Disease"
  • Digital Pathology Association lectures at University of Nagasaki Nagasaki, Japan September 3, 2018
  • Main Speaker at 7th Edition of the Digital Pathology course Cadiz, Spain October 15, 2019
  • Invited Lecturer at 3rd Annual Digital Pathology and AI Workshop Pittsburgh, PA December 13, 2019
  • Invited Lecturer at MEDLAB Dubai 2020 Dubai, UAE February 6, 2020
  • 2014 United States and Canadian Pathology (USCAP) Practice Changers Talk "Integration of Smartphone Technology into the Practice of Anatomic Pathology"
Education & Training
BA - 1999, Xavier University
MD - 2004, University of Cincinnati College of Medicine
AP/CP Pathology Residency - 2008, University Hospitals of Cleveland/Case Western Reserve University
Pathology Fellowship - 2009, Gastrointestinal Pathology, University of Pittsburgh Medical Center
Research Interests

Dr. Hartman's current primary research interests are in the field of idiopathic inflammatory bowel disease: underlying mechanisms, molecular pathogenesis of dysplasia development; associated disorders; and post-surgical complications. Other areas of research include peritoneal mesothelioma, molecular abnormalities in colon cancer, and the application of pathology informatics. Dr. Hartman is a co-investigator on institutional grants. Dr. Hartman is actively involved in research for digital pathology, image analysis and artificial intelligence/machine learning.

Representative Publications

View Dr. Hartman's publications on PubMed.

  • Pai RK, Hartman DJ, Leighton JA, Pasha SF, Ramos Rivers C, Regueiro M, Binion DG, Pai RK. Validated Indices for Histopathologic Activity Predict Development of Colorectal Neoplasia in Ulcerative Colitis. J Crohns Colitis Epub 2021 Feb 12.
  • Hartman D, Chandran U, Davis M, Dhir R, Shirey WE, Silverstein JC, and Becich MJ. Clinical and Research Informatics Data Strategy for Precision Oncology. 2020 in Holland Frei Textbook of Cancer Medicine.
  • Pantanowitz L, Wu U, Seigh L, LoPresti E, Yeh FC, Salgia P, Michelow P, Hazelhurst S, Chen WY, Hartman D, Yeh CY. Artificial Intelligence-Based Screening for Mycobacteria in Whole-Slide Images of Tissue Samples. Am J Clin Pathol. 2021 Feb 2. PMID: 33527136.
  • Pai RK, Hartman D, Schaeffer DF, Rosty C, Shivji S, Kirsh R, Pai RK. Development and Initial Validation of a Deep Learning Algorithm to Quantify Histologic Features in Colorectal Carcinoma Including Tumour Budding/Poorly Differentiated Clusters. Histopathology Epub 2021 Feb 15. PMID: 33590485.
  • Pantanowitz L, Hartman D, Qi Y, Choo EY, Suh B, Paeng K, Dhir R, Michelow P, Hazelhurst S, Song SY, Cho SY. Accuracy and Efficiency of an Artificial Intelligence Tool When Counting Breast Mitoses. Diagn Pathology. 2020 Jul 4;15(1):80. PMID: 32622359.
  • Hartman DJ, Gurcan MN, van der Laak JVM, Pantanowitz L. Value of Public Challenges for the Development of Pathology Deep Learning Algorithms. J Pathol Inform, 2020 Feb 26;11:7. PMID: 32318315.
  • Hartman DJ, Frank M, Seigh L, Choudry H, Pingpank J, Holtzman M, Bartlett D, Bahary N, Pantanowitz L, Pai RK. Automated Quantitation of CD8-Positive T-cells Predicts Prognosis in Colonic Adenocarcinoma with Mucinous, Signet Ring Cell, or Medullary Differentiation Independent of Mismatch Repair Protein Status. Am J Surg Path 2020 Jul;44(7):991-1001. PMID: 32205483.
  • Pai RK, Binion DG, Regueiro MD, Schwartz M, Magos C, Hartman DJ, Pai RK. Complete Resolution of Mucosal Neutrophils Associates with Improved Long-Term Clinical Outcomes in Ulcerative Colitis. Clin Gastoenterol Hepatol. 2020 Oct; 18(11): 2510-2517. PMID: 31843598.
  • Ma C, Henn P, Binion DG, Miller C, Herbst C, Hartman DJ, Pai RK. Loss of SATB2 Expression is a Biomarker of Inflammatory Bowel Disease-Associated Colorectal Dysplasia and Adenocarcinoma. Am J Surg Pathol. 2019 Oct; 43(10): 1314-1322. PMID: 31318711.
  • Uttam S, Hashash JG, LaFace J, Binion D, Regueiro M, Hartman DJ, Brand RE, Liu Y. Three-Dimensional Nanoscale Nuclear Architecture Mapping of Rectal Biopsies Detects Colorectal Neoplasia in Patients with Inflammatory Bowel Disease. Cancer Prev Res. 2019 Aug; 12(8): 527-538. PMID: 31164345.
  • Aeffner F, Zarella MD, Buchbinder N, Bui MM, Goodman MR, Hartman DJ, Lujan GM, Molani MA, Parwani AV, Lillard K, Turner OC, Vemuri VNP, Yuil-Valdes AG, Bowman D. Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association. J. Pathol Inform. 2019 Mar 8; 10: 9 PMID: 30984469.
  • Hartman DJ, Ahmed F, Ferris RL, Rimm DL, Pantanowitz L. Utility of CD8 Score by Automated Quantitative Image Analysis in Head and Neck Squamous Cell Carcinoma. Oral Oncol. 2018 Nov; 86: 278-287 PMID: 30409313.
  • Mitchell KM, Kluger H, Snzol M, Hartman DJ. Ipilimumab induced perforating colitis. J Clin Gastroenterol. 2013 Oct;47(9):781-5. Epub 2013 Apr 29. PMID: 23632354.
  • Bista RJ, Uttam S, Hartman DJ, Qiu W, Yu J, Zhang L, Brand RE, Liu Y. Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model. J. Biomed. Opt. 2012 Jun; 17(6), 066014. doi: 10.1117/1.JBO.17.7.066014. PMID: 22734770.
  • Hartman DJ, Slivka AS, Giusto DA, Krasinskas AM. Tissue yield and diagnostic efficacy of fluoroscopic and cholangioscopic techniques to assess indeterminate biliary strictures. Clin Gastro and Hepatol 2012 Sep; 10(9):1042-6. doi: 10.1016/j.cgh.2012.05.025. Epub 2012 Jun 4. PMID: 22677575.
  • Hartman DJ, Davison JM, Foxwell TJ, Nikiforova MN, Chiosea SI. Mutant Allele Specific Imbalance Modulates Prognostic Impact of KRAS Mutations in Colorectal Adenocarcinoma and is Associated with Worse Overall Survival. Int J Cancer. Oct 15;131(8):1810-7. doi: 10.1002/ijc.27461. Epub 2012 Mar 22. PMID: 22290300.
  • Zarella MD, Bowman D, Aeffner F, Farahani N, Xthona A, Absar SF, Parwani A, Bui M, Hartman DJ. A Practical Guide to Whole Slide Imaging: A White Paper From the Digital Pathology Association. Arch Pathol Lab Med. Epub 2018 Oct 11. PMID: 30307746.
  • Hartman DJ, Binion DG, Regueiro MD, Miller C, Herbst C, Pai RK. Distinct Histopathologic and Molecular Alterations in Inflammatory Bowel Disease-Associated Intestinal Adenocarcinoma: c-MYC Amplification is Common and Associated with Mucinous/Signet Ring Cell Differentiation. Inflamm Bowel Dis. 2018 Jul 12; 24(8): 1780-1790. Epub 18 May 2018. PMID: 29788391.
  • Hartman DJ, Borczuk A, Dacic D, Krasinskas A. Reproducibility for Histologic Parameters in Peritoneal Mesothelioma. Hum Pathol. 2017 Sep; 67: 54-59. Epub 2017 Jul 13. PMID: 28712777.
  • Hartman DJ, Pantanowitz L, McHugh JS, Piccoli AL, O'Leary MJ, Lauro GR. Enterprise Implementation of Digital Pathology: Feasibility, Challenges, and Opportunities. J Digit Imaging, 2017 Oct;30(5):555-560. Epub 2017 Jan 23. PMID: 28116576.
  • Guo H, Birsa J, Farahani N, Hartman DJ, Piccoli A, O'Leary M, McHugh J, Nyman M, Stratman C, Kvarnstrom V, Yousem SA, Pantanowitz L. Digital Pathology and Anatomic Pathology Laboratory Information System Integration to Support Digital Pathology Sign-out. J Pathol Inform. 2016; 7:23 (Epub 04 May 2016) PMID: 27217973.
  • Zhao C, Wu T, Ding X, Parwani AV, Chen H, McHugh J, Piccoli A, Xi Q, Gonzalo RL, Feng X, Hartman DJ, Seethala RR, Wu S, Yousem S, Liang Y, Pantanowitz L. International Telepathology Consultation: Three Years of Experience Between the University of Pittsburgh Medical Center and KingMed Diagnostics in China. J Pathol Inform, 2015 Nov 27;6:63. PMID: 26730353.
  • Koutroubakis IE, Regueiro M, Schoen RE, Ramos-Rivers C, Hashash JG, Schwartz M, Swoger J, Barrie A, Baidoo L, Dunn MA, Hartman D, Binion DG. Multiyear Patterns of Serum Inflammatory Biomarkers and Risk of Colorectal Neoplasia in Patients with Ulcerative Colitis. Inflamm Bowel Dis. 2016 Jan; 22(1): 100-5. PMID: 26355468.
  • Krasinskas AM, Borczuk AC, Hartman DJ, Chabot JA, Taub RN, Mogal A, Pingpank J, Bartlett D, Dacic S. Prognostic Significance of Morphologic Growth Patterns and Mitotic Index of Epithelioid Malignant Peritoneal Mesothelioma. Histopathology, 2016 Apr;68(5):729-37 (Epub 2015 Aug 14). PMID: 26272336.
  • Hartman DJ, Binion DG, Bahary N, Sun W, Schraut W, Reguiero M, Nikiforova MN, Pai RK. Isocitrate Dehydrogenase-1 is Mutated in Inflammatory Bowel Disease-Associated Intestinal Adenocarcinoma with Low-Grade Tubuloglandular Histology But Not in Sporadic Intestinal Adenocarcinoma. Am J Surg Pathol 2014 Aug;38(8):1147-56. PMID: 25029120.
  • Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Downs-Kelly E, Goldblum JR, Liu X, Patil DT, Bennett AE, Plesec TP, Kuan SF, Nikiforova MN, Shadrach B,Pai RK. Serrated Lesions of the Appendix Frequently Harbor KRAS Mutations and Not BRAF Mutations Indicating a Distinctly Different Serrated Neoplastic Pathway in the Appendix. Human Pathol. 2014 Feb;45(2):227-35. Epub 2013 Oct 30. PMID: 24439221.
  • Hartman DJ, Brand RE, Hu H, Bahary N, Dudley B, Chiosea SI, Nikiforova MN, Pai RK. Lynch Syndrome-Associated Carcinoma: Frequent Involvement of the Left Colon and Rectum and Late-Onset Presentation Supports a Universal Screening Approach. Hum Pathol. 2013 Nov; 44(11):2518-28 Epub 2013 Sep 10. PMID: 24034859.
  • Hartman DJ, Nikiforova MN, Chang DT, Chu E, Bahary N, Brand RE, Zureikat A, Zeh HJ, Pingpank J, Bartlett D, Pai RK. Signet Ring Cell Colorectal Carcinoma: A Distinct Subset of Mucin-Poor Microsatellite Stable Signet Ring Carcinoma Associated with Dismal Prognosis. Am J Surg Pathol. 2013 Jul; 37(7): 969-77. PMID: 23681075.
  • Bista RJ, Wang P, Bhargava R, Hartman DJ, Uttam S, Brand RE, Liu Y. Nuclear nano-morphology markers of histologically normal cells detect the "field effect" of breast cancer. Breast Cancer Res and Treat. 2012 Aug; 135(1):115-24. Epub 2012 Jun 16. PMID: 22706633.
  • Goodell PP, Krasinskas AM, Davison JM, Hartman DJ. Comparison of methods for proliferative index analysis for grading pancreatic well-differentiated neuroendocrine tumors. Am J Clin Pathol. 2012 Apr;137(4):576-82. PMID: 22431534.