Dr. Hu is a member of the Division of Experimental Pathology.
Education & Training
PhD - Chinese Academy of Sciences and Peking Union Medical College, Beijing, 2005
MS - Chinese Academy of Sciences, Beijing, 2001
Research Interests
Signal transduction including Wnt, TGF-β, ER and NF-κB in carcinogenesis; Cell Cycle; Protein post-translational modification.
Representative Publications
View Dr. Hu's publications on PubMed.
- Hu D, Zhou Z, Davidson NE, Huang Y, Wan Y. Novel insight into KLF4 proteolytic regulation in estrogen receptor signaling and breast carcinogenesis. J. Biol. Chem., 2012; 287(17): 13584-97. PMID: 22389506
- Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K. Critical and reciprocal regulation of KLF4 and SLUG in TGFβ-initiated prostate cancer EMT. Mol. Cell Biol., 2012; 32(5): 941-53. PMID: 22203039
- Hu D, Qiao X, Wu G, Wan Y. The emerging role of APC/C-Cdh1 in development. Semin. Cell Dev. Biol., 2011; 22(6): 579-85. PMID: 21497201
- Hu D, Wan Y. Regulation of Kruppel-like factor 4 by the Anaphase Promoting Complex pathway is involved in TGF-β Signaling. J. Biol. Chem., 2011; 286(9): 6890-901. PMID: 21177849
- Hu D*, Liu W*, Wu G, Wan Y. Nuclear translocation of Skp2 facilitates its destruction in response to TGF-β signaling. Cell Cycle, 2011; 10(2): 285-92. (* equal contribution) PMID: 21212736
- Benavides MA, Hu D, Baraoidan MK, Bruno A, Du P, Lin S, Yang W, Bland KI, Grizzle WE, Bosland MC. L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells. J Cancer Res. Clin. Oncol., 2011; 137(3): 441-53. PMID: 20454975