Clayton A Wiley, MD, PhD

Division Director, Neuropathology, PERF Professor of Pathology

Dr. Wiley is Director of the Division of Neuropathology. In addition to clinical sign out, Dr. Wiley directs the Neuropathology fellowship program and runs an NIH funded research program studying neuroinflammation and viral encephalitis in particular.


Board certified in AP and NP, 1985



Clinical Expertise

Board certified in Neuropathology with specific expertise in infectious disease.

Education & Training
MD - University of California, San Diego, 1981
PhD - University of California, San Diego, 1981
Fellow American Association for Advancement of Science
Research Interests

Dr. Wiley's research concentrates on the pathogenesis of neurodegenerative diseases and in particular on viral and age induced nervous system diseases. Viruses damage the nervous system either by direct infection of neural cells or by secondary effects of an immune response. In recent years his studies have focused on central nervous system RNA virus infections (e.g. influenza, arboviruses and retroviral) and have pioneered the use of molecular and imaging techniques to quantitatively assess viral burden. This same technology is now being applied to quantify neurological damage and the immune / neuroinflammatory response with specific attention focused on disruption of the extracellular matrix and how this leads to synaptic damage. Dr. Wiley is not currently taking on graduate students.

Dr. Wiley discusses how viral infections are related to dementia

NIH Research

View Dr. Wiley's NIH RePORT on

Representative Publications

View Dr. Wiley's publications on PubMed

  • Chimelli, L, Melo, ASO, Avvad-Portari, E, Wiley, CA, Camacho, AHS, Lopes, VS, Machado, HN, Andrade, CV, Dock, DCA, Moreira, ME, Tovar?Moll, F, Oliveira?Szejnfeld, PS, Carvalho, ACG, Ugarte, ON, Batista, AGM, Amorim, MMR., Melo, FO, Ferreira, TA, Marinho, JRL, Azevedo, GS, Leal, JIBF, da Costa, RFM, Rehen, S, Arruda, MB, Brindeiro, RM, Delvechio, R, Aguiar, RS and Tanuri, A. The spectrum of neuropathological changes associated with congenital Zika virus infection. Acta Neuropathologica (2017) 133:983-999, PMID: 28332092.
  • Wiley, CA and Chimelli, L Human Zika and West Nile Virus Neurological Infections: What is the difference? Neuropathology (2017) 37:393-399. PMID: 28493351.
  • Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN. Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues. PLoS Pathogens.(2017) 13(3):e1006219. PMID: 28332092.
  • Thomas DL, Manners J, Marker D, Mettenburg J, Murdoch G, Stevens B, Wang G, Wiley C CD8-Positive T-Cell Leukoencephalitis With Astrocytopathy Clinically Presenting as Neuromyelitis Optica. Journal of neuropathology and experimental neurology. (2017) 76(5):347-57. PMID: 28340257.
  • Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ Jr, Maiello P, Scanga CA, Bowling JD, Bouwer AL, Duangkhae PA, Wiley CA, Flynn JL, Wang J, Cole KS, Perez DR, Reed DS, Barratt-Boyes SM. Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques. J Immunol 198 (4): 1616-1626 PMID: 28062701.
  • Bissel, SJ, Gurnsey, K, Jadema, HP, Smith, NF, Wang, G, Bradberry, CW and Wiley, CA: Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. Retrovirology (2018) 15 (1):17 PMID: 29391069.
  • Chimelli L, Pone SM, Avvad-Portari E, Vasconcelos ZFM, Zin AA, Cunha DP, Thompson NR, Moreira REL, Wiley CA and Pone, MVS: Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. J Neuropathol Exp Neurol Vol. 77, No. 3, March 2018, pp. 193-198. PMID: 29346650.
  • Jorgensen DR, Shaaban EC, Wiley CA, Gianaros PJ, Mettenburg J, Rosano C; Cerebral small vessel 1 disease in older age as a heterogeneous phenomenon. American Journal of Physiology Heart and Circulatory Physiology 2018 Jun 1;314(6):H1117-H1136. doi: 10.1152/ajpheart.00535.2017. Epub 2018 Feb 2. PMID: 29393657.
  • Dietz RL, Hartman DJ, Zheng L, Wiley C, Pantanowitz L. Review of the use of telepathology for intraoperative consultation. Expert Rev Med Devices. 2018. Epub 2018/11/20. doi: 10.1080/17434440.2018.1549987. PMID: 30451027.
  • Emery SP, Green S, Murdoch G and Wiley CA; Histologic appearance of iatrogenic obstructive hydrocephalus in the fetal lamb model. Fetal Diagn Ther. 2019 Apr 11:1-9. doi: 10.1159/000497360. PMID: 30974442.
  • Mettenburg JM, Branstetter BF, Wiley CA, Lee P, Richardson RM; Improved Detection of Subtle Mesial Temporal Sclerosis: Validation of a Commercially Available Software for Automated Segmentation of Hippocampal Volume. Am J Neuroradiol 2019 40(3):440-445 doi: 10.3174/ajnr.A5966. Epub 2019 Feb 7 PMID: 30733255.
  • Wiley CA; Neuropathology on Trial. Journal of Neuropathology and Experimental Neurology, 2019 doi: 10.1093/jnen/nlz137.
  • Baskota SU, Wiley CA, Pantanowitz L: Next Generation Robotic Microscopy for Intraoperative Teleneuropathology Consultation, J Pathol Inform 2020, 11:13 (23 April 2020) doi: 10.4103/jpi.jpi_2_20.
  • Wiley CA: Emergent viral infections of the CNS. Journal of Neuropathology and Experimental Neurology. Submitted