Assistant Professor of Medicine
Office Location:
3459 Fifth Ave
NW 628.4 MUH
Pittsburgh, PA 15213-3236
Contact Information:
Office Telephone: 412-864-5483
Lab Telephone: 412-383-0106
Email: lhzhang@pitt.edu
Research Interests
My laboratory studies lung vascular biology and immuno-pathogenesis of acute lung injury. Our research focuses on the mechanism of respiratory viruses-induced lung vascular injury and signals network between endothelial cells and immune cells during the innate and adaptive immune response. The SARS-CoV-2 and H1N1-induced acute lung injury models are two major animal models used in the laboratory. We are also interested in lung vascular regeneration and mechanisms of transcriptional regulation in the vasculature. By understanding the mechanisms by which regulate the balance between inflammatory injury and regeneration in viral lung injury, we will be able to develop new therapies that minimize inflammatory injury, maximize tissue repair and reduce patient mortality.
Selected Publications:
Lianghui Zhang*, Krishna K Narayanan, Laura Cooper, Kui K Chan, Christine A Devlin, Aaron Aguhob, Kristie Shirley, Lijun Rong, Jalees Rehman*, Asrar B Malik*, Erik Procko*. An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2. EMBO Molecular Medicine. 2022 Sep 12:e16109. PMID: PMC36094679
* Co-corresponding authorship
Lianghui Zhang*, Shang Gao, Zachary White, Yang Dai, Asrar B. Malik and Jalees Rehman*. Single-Cell Transcriptomic Profiling Identifies Dynamic Inflammatory and Regenerative Subpopulations Following Vascular Injury. JCI Insight 2022 Jun 8;7(11):e158079. PMCID: PMC9220950
* Co-corresponding authorship
Lianghui Zhang*, Soumajit Dutta, Shiqin Xiong, Matthew Chan, Kui K. Chan, Timothy M. Fan, Keith L. Bailey, Matthew Lindeblad, Laura M. Cooper, Lijun Rong, Anthony Gugliuzza, David D. Ho, Diwakar Shukla*, Erik Procko*, Jalees Rehman*, Asrar B. Malik*. An engineered high affinity ACE2 peptide therapeutically mitigates lung vascular injury and mortality induced by distinct SARS-CoV-2 variants. Nature Chemical Biology, 2022 Mar;18(3):342-351. PMCID: PMC8885411.
* Co-corresponding authorship
Ankit Jambusaria, Zhigang Hong, Lianghui Zhang, Shubhi Srivastava, Arundhati Jana, Peter T. Toth, Yang Dai, Asrar B. Malik and Jalees Rehman. Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation. Elife. 2020 Jan 16;9. doi: 10.7554/eLife.51413. PMCID: PMC7002042.
Menglin Liu*, Lianghui Zhang*, Glenn Marsboom, Ankit Jambusaria, Shiqin Xiong, Peter T. Toth, Elizaveta V. Benevolenskaya, Jalees Rehman & Asrar B. Malik. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Nature Communications 2019 May 9;10(1):2126. PMCPMCID: PMC6509327.
* Co-first authorship
Lianghui Zhang, Ankit Jambusaria, Zhigang Hong, Glenn Marsboom, Peter T. Toth, Brittney-Shea Herbert, Asrar B. Malik, Jalees Rehman. SOX17 Regulates Conversion of Human Fibroblasts into Endothelial Cells and Erythroblasts by Dedifferentiation into CD34+ Progenitor Cells. Circulation. 2017 Jun 20;135(25):2505-2523. PMCID: PMC5472005
Lianghui Zhang, Sundeep Malik, Jinjiang Pang, Huan Wang, Keigan M. Park, David I. Yule, Burns C. Blaxall and Alan V. Smrcka. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 2013 Mar 28;153(1):216-27. PMCID: PMC3615249
Complete List of Published Work in MyBibliography:
https://www.ncbi.nlm.nih.gov/myncbi/1d3keqahzC15z/bibliography/public/