Division of Clinical Hematopathology

CD123 immunohistochemical stain, Castleman Disease
CD123 immunohistochemical stain, Castleman Disease

The Division of Hematopathology, based at UPMC Presbyterian, has a broad and varied agenda achieving the classic academic triad of service, education and research. The Division includes nine faculty members with varied areas of expertise, two fellows and an administrative staff. All faculty practice diagnostic hematopathology including interpretation of morphologic, immunophenotypic, molecular and cytogenetic studies. They also each have specific areas of expertise and administrative responsibilities.

Clinical Services

Image of flow cytometry analysisThe Division serves as the diagnostic hematopathology resource for the UPMC Health System as well as for others in our region and beyond. It is directly responsible for all of the diagnostic hematopathology at UPMC Presbyterian and UPMC Shadyside Hospitals, UPMC Children's Hospital of Pittsburgh, UPMC Magee-Womens Hospital and the Hillman Cancer Center. In addition to a diagnostic lymph node/solid tissue and adult and pediatric bone marrow services, the Division provides the medical direction for a large Clinical Flow Cytometry Laboratory, a bone marrow laboratory and general hematology laboratories. The Division has active Consultation Services accepting both fresh specimens for full evaluation or for special studies as well as previously fixed specimens. We emphasize a multiparameter approach to hematopathology that incorporates morphology, flow cytometric and paraffin section immunophenotypic data, genotypic data and classical and fluorescence in situ hybridization (FISH) cytogenetic data.

Research Activities

The Division emphasizes several major areas of investigation. A large area of ongoing investigations is the use of a multiparameter approach in the study principally of the non-Hodgkin lymphomas and related lymphoid proliferations as well as myeloid neoplasms. Specific areas of interest have included MALT lymphomas, other small B-cell lymphomas, aggressive B-cell lymphomas, cutaneous lymphomas, post-transplant lymphoproliferative disorders and myeloid neoplasms. Techniques range from standard morphology to complex genotypic studies including next generation sequencing. The role of flow cytometric studies in dealing with selected problems in diagnostic hematopathology such as myeloid neoplasms is another specific area of interest as is the evaluation of new instrumentation in diagnostic hematology. The Division also provides support for studies undertaken by our clinical colleagues.


The Division is active in medical student education including a senior elective in hematopathology, active participation in the second year hematology course, and some graduate student education. The Division also has an ACGME accredited fellowship program (Hematopathology Fellowship). Much of our educational efforts are spent on resident education and on training our hematopathology fellows. Rotations are also provided for clinical hematology/oncology fellows and other fellows in our department. Divisional members are also involved in a variety of national/international teaching activities.


The core hematopathology rotation of approximately 16 weeks divided into a junior and senior rotation offers the resident an introduction to many facets of this complex field. The resident will begin to become familiar with the multiparameter approach to adult and pediatric diagnostic hematopathology (bone marrows and lymph nodes) as well as with techniques used in the hematology and the flow cytometry laboratories. Finally he/he will learn about major neoplastic and non-neoplastic disease entities that involve the hematopoietic and lymphoid cell lineages. If interested, more advanced rotations can be arranged in one or more areas within the division.

Core Curriculum for Residents

Junior Rotation

  • Laboratory hematology / clinical marrow experience / Flow Cytometry Laboratory (1 week)
  • Pediatric hematopathology / laboratory hematology (2 weeks)
  • Adult bone marrow pathology (2 weeks)
  • Lymph node / solid tissue hematopathology (3 weeks)

Senior Rotation

  • Lymph node / solid tissue hematopathology (3 weeks)
  • Pediatric hematopathology / laboratory hematology (1 week)
  • Adult bone marrow pathology (3 weeks)
  • Flow cytometry service / laboratory hematology (1 week)
Flow Cytometry Lab

Follow this link to learn more about the Flow Cytometry Lab.