David Alan Vorp, PhD

Education

  • BS - 1986, University of Pittsburgh
  • PhD - 1992, University of Pittsburgh

Research Interests

As the Director of the Vascular Bioengineering Research Lab, Dr. Vorp's research focuses on vascular biomechanics. He is currently studying the biomechanical evaluation of abdominal and thoracic aortic aneurysms in patients with and without heritable disorders, and the bioengineering and biological studies of aneurysm weakening. Dr. Vorp has published more than 100 peer-review research manuscripts and 40 of them are focused on the biomechanics of aortic aneurysms. He has several patents in the field of vascular mechanics and is a co-founder of the start-up Neograft Technologies, Inc., a company that applies technology developed in Dr. Vorp's laboratory relating to biodegradable support for arterial vein grafts.

Awards and Honors

ASME Van C. Mow Medal and delivered the associated lecture at the annual Summer Bioengineering Conference, June 2011

Selected Publications

View Dr. Vorp's publications on PubMed

NOTE: * - Dr. Vorp served as the supervising or corresponding author

  1. *Soletti L, Hong Y, Guan J, Stankus JJ, El-Kurdi MS, Wagner WR, Vorp DA, “A Bi-Layered Elastomeric Scaffold for Tissue Engineering of Small-Diameter Vascular Grafts,” Acta Biomaterialia 6(1):110-22, 2010. PMID: 19540370.
  2. Remlinger NT, Czajka CA, Juhas ME, Vorp DA, Stolz DB, Badylak SF, Gilbert S, Gilbert TW, "Hydrated Xenogeneic Decellularized Tracheal Matrix as a Scaffold for Tracheal Reconstruction," 31(13): 3520-3526, 2010. PMID: 20144481.
  3. *Nieponice A, Soletti L, Guan J, Hong Y, Gharaibeh B, Maul TM, Huard J, Wagner WR, Vorp DA, “In Vivo Assessment of a Tissue-Engineered Vascular Graft Combining a Biodegradable Elastomeric Scaffold and Muscle-Derived Stem Cells in a Rat Model,” Tissue Eng Part A 16(4) 1215-23, 2010. PMID: 19895206.
  4. Doyle BJ, Cloonan AJ, Walsh MT, Vorp DA, McGloughlin TM, “Identification of Rupture Locations in Patient-Specific Abdominal Aortic Aneurysms Using Experimental and Computational Techniques,” J Biomech 43(7):1408-16. 2010. PMID: 20152982. PMCID: PMC2857518.
  5. *Prantil-Baun R, de Groat WC, Miyazato M, Chancellor MB, Yoshirmura N, Vorp DA, “Ex Vivo Biomechanical, Functional, and Immunohistochemical Alterations of Adrenergic Responses in the Female Urethra in a Rat Model of Birth Trauma,” Am J Physiol Renal Physiol Aug:299(2):F316-24,2010. PMID: 20444739.
  6. Soares JS, Pasta S, Vorp DA, Moore JE Jr, “Modeling in Cardiovascular Biomechanics,” Inl J Eng Sci, 48(11); 1563-1575,2010
  7. *He W, Nieponice A, Soletti L, Hong Y, Gharaibeh B, Crisan M, Usas A, Peault B, Huard J, Wagner WR, Vorp DA, “Pericyte-Based Human Tissue Engineered Vascular Grafts: Fabrication, Characterization and Preliminary In Vivo Assessment,” Biomaterials, Nov;31(32):8235-44,2010. PMID: 20684982
  8. Ferruzzi J, Vorp DA, Humphrey JD, “On Constitutive Descriptors of the Biaxial Mechanical Behaviour of Human Abdominal Aorta and Aneurysms”, J Roy Soc Interface, Mar 6;8(56):435-50,2010 PMID: 20659928
  9. Zeinali-Davarani S, Raguin LG, Vorp DA, Baek S, “Identification of In Vivo Material and Geometric Parameters of a Human Aorta: Toward Patient-Specific Modeling of Abdominal Aortic Aneurysm”, Biomech Model Mechanobiol 10(5): 689-699, 2011. PMID: 21053043.
  10. *Maul TM, Chew DW, Nieponice A, Vorp DA, “Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation” Biomech Model Mechanobiol. 10(6): 939-953, 2011. doi: 10.1007/s10237-010-0285-8. PMID: 21253809.
  11. *Soletti L, Nieponice A, Hong Y, Ye SH, Stankus JJ, Wagner WR, Vorp DA, “In Vivo Performance of a Phospholipid-Coated Bioerodable Elastomeric Graft for Small-Diameter Vascular Applications”, J Biomed Mat Res: Part A, Feb;96(2):436-48, 2011 doi: 10.1002/jbm.a.32997. PMID: 21171163.
  12. *He W, Nieponice A, Hong Y, Wagner W, Vorp DA, “Rapid Engineered Small Diameter Vascular Grafts from Smooth Muscle Cells”, Cardiovascular Engineering and Technology Volume 2, Number 3, Sept,149-159, 2011, doi: 10.1007/s13239-011-0044-8
  13. Udelsman B, Hibino N, Villalona GA, McGillicuddy EA, Nieponice A, Sakamoto Y, Matsuda S, Vorp DA, Shinoka T, Breuer C, “Development of an operator independent method for seeding tissue engineered vascular grafts”, Tissue Eng Part C Methods, Jul;17(7):731-6, 2011 PMID: 21410308
  14. Kitta T, Haworth-Ward DJ, Miyazato M, Honda M, de Groat WC, Nonomura K, Vorp DA, Yoshimura N, “Effects of ovariectomy and estrogen replacement on the urethral continence reflex during sneezing in rats”, Journal of Urology Volume 186,Oct,1517-1523,2011. doi: 10.1016/j.juro.2011.05.045. PMID: 21855912.
  15. *Haworth DJ, Kitta T, Morelli B, Chew DW, Yoshimura N, de Groat WC, Vorp DA, “Strain-dependent urethral response”, Neurourology and Urodynamics, Nov;30(8):1652-8, 2011 doi: 10.1002/nau.21158. PMID: 21826722.
  16. *Pasta S, Phillippi JA, Gleason TG, Vorp DA, “The Effect of Aneurysm on the Mechanical Dissection Properties of the Human Ascending Aorta”, Journal of Thoracic and Cardiovascular Surgery, Feb;143(2):460-7, 2012. PMID: 21868041.
  17. *Krawiec JT, Vorp DA, “Adult Stem Cell-Based Tissue Engineered Blood Vessels: A Review”, Biomaterials, Apr;33(12):3388-400, 2012, doi: 10.1016/j.biomaterials.2012.01.014.