Cytopathology
Case Prepared By: Mason Marshall, D.O. and Samer Khader, M.D.
Case Presentation:
A male patient in his sixties presented with flank pain and early satiety. A recent colonoscopy (only up to the hepatic flexure) was unremarkable. A CT scan revealed a large partially cystic 14 x 13 cm retroperitoneal mass. An ultrasound-guided fine needle aspiration and core needle biopsy were performed on the mass.
Biopsy Results:
Immunohistochemistry:
The tumor cells are positive for PAN-CK, CK20, CK7, SATB2, CDX2 in the glandular component, while positive for GATA3 and patchy positive for SALL-4 in the solid component. Chromogranin, synaptophysin, CD56, PSA, PAX-8, p40, calretinin, and WT1 are all negative.
The specimen was also sent for FISH studies: